In a medium bowl whisk together the flour, chili powder, kosher salt, black pepper, and cayenne until evenly combined.
Add the egg and milk to the seasoned flour mixture and whisk until smooth.
Place the chicken tenders into the bowl and stir or toss to coat each piece completely in the wet flour mixture.
Put the panko breadcrumbs in a separate shallow bowl. Using tongs or your fingers, press each coated chicken piece into the panko to fully cover, then transfer the crumb-coated strips to a plate.
For stovetop: heat 2 tablespoons olive oil in a large stainless steel skillet over medium-high until shimmering. Add half of the chicken in a single layer and cook undisturbed about 2 minutes per side, or until browned and cooked through. Repeat with remaining chicken.
For oven: preheat the oven to 425°F (218°C). Place a wire rack on a rimmed baking sheet and lightly grease the rack. Arrange the crumb-coated chicken in a single layer on the rack, spray or brush with oil, and bake 10 minutes or until cooked through.
Transfer the cooked chicken to a serving plate. Squeeze lime wedges over the chicken and drizzle with honey just before serving.