Pat the 2 pounds of chicken drumettes dry with paper towels and place them in a large mixing bowl.
Drizzle 1 tablespoon extra-virgin olive oil over the drumettes and toss with tongs or your hands until evenly coated.
Sprinkle 1 teaspoon garlic powder, 1/2 teaspoon Italian seasoning, 1 teaspoon onion powder, 1/2 teaspoon black pepper, 1/2 teaspoon smoked paprika, a pinch of cayenne, and kosher salt to taste over the chicken.
Toss the drumettes thoroughly so all pieces are evenly seasoned.
Preheat the air fryer to 400°F (about 5 minutes) if your model requires preheating.
Arrange the wings in a single layer in the air fryer basket without overcrowding; cook in batches if necessary.
Air fry at 400°F for 20 minutes, flipping the wings halfway through cooking, until the skin is crisp and the internal temperature reaches 165°F.
Remove the wings from the air fryer and let rest briefly before serving.