In a small bowl, combine the salt, chili powder, onion powder, garlic powder, and cayenne pepper.
Sprinkle the spice mixture evenly over both sides of the chicken tenders.
Heat a 12-inch non-stick skillet over medium-high heat and melt half of the butter (about 2 tablespoons).
Add the seasoned chicken tenders to the skillet and cook until cooked through and browned, about 8 minutes, turning as needed.
Reduce the heat to medium-low, pour in the heavy cream and add the remaining butter, stirring to combine.
Simmer the sauce until it thickens, about 5–7 minutes, spooning sauce over the chicken.
Serve the chicken with the sauce spooned over it, optionally over pasta or mashed potatoes.