Preheat the oven to 400°F (200°C). Line a baking sheet with parchment paper or lightly grease it and set aside.
Rice the broccoli in a food processor or finely shred it with a box grater until it resembles rice.
Place the riced broccoli in a microwave-safe bowl, cover, and microwave 1–2 minutes until steamed; let cool for about 1 minute.
Transfer the warm broccoli to a clean kitchen towel or cheesecloth and squeeze firmly to remove as much liquid as possible, until you have a fairly dry ball of broccoli.
In a mixing bowl, combine the drained broccoli, eggs, Parmesan, 1/4 cup mozzarella, salt, pepper, and optional Italian seasoning until evenly mixed.
Spread the broccoli mixture onto the prepared baking sheet and shape it into a 1/2-inch thick round or rectangle to form the crust.
Bake the crust for 10–12 minutes, or until lightly browned and set.
Remove the crust from the oven, spread the pizza sauce over it, and sprinkle evenly with the remaining 1 cup cheese and any desired vegetable toppings.
Return to the oven and bake another 10–12 minutes, or until the cheese is fully melted and bubbly.
Let the pizza cool at least 5 minutes before slicing and serving.