Preheat the oven to 425°F (220°C). Line a baking sheet with aluminum foil.
Place the halibut fillet on the prepared baking sheet, skin side down if present, and sprinkle evenly with 1 teaspoon kosher salt and 1/2 teaspoon black pepper.
Melt 4 tablespoons unsalted butter in a small saucepan over low heat or in a microwave-safe bowl. Stir in the minced garlic, 1/2 teaspoon garlic powder, and the lemon zest until combined.
Brush the melted garlic-lemon butter evenly over the top of the halibut.
Bake in the preheated oven for 9–15 minutes, depending on thickness, until an instant-read thermometer inserted into the thickest part reads 145°F (63°C) and the fish flakes easily with a fork.
Serve immediately with lemon wedges.